Preimplantation genetic testing for aneuploidy increases the live-birth rate in older women

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The findings of a recent study on advanced age women who undergo preimplantation genetic testing for aneuploidy showed that they have a greater chance of having live-birth than women who did not undergo such testing.

The result of the study was published in the journal, Obstetrics and Gynecology. It included 3,334 women participants from nine trials who were undergoing in vitro fertilization (IVF) after having a prenatal genetic diagnosis to allow only genetically normal embryos to be transferred. IVF is a medical procedure in which an egg is fertilized by the sperm in a test tube under laboratory conditions or outside the body.

Based on the study result, it was concluded that women who underwent a comprehensive chromosome screening-based preimplantation genetic testing, had a greater chance of having live-birth. This was especially true for women who were in advanced maternal age group unlike non-advanced age women.   

Source: Cheng X, Zhang Y, Deng H, Feng Y, Chong W, Hai Y, Hao P, He J, Li T, Peng L, Wang P, Xiao Y, Fang F. Preimplantation Genetic Testing for Aneuploidy With Comprehensive Chromosome Screening in Patients Undergoing In Vitro Fertilization: A Systematic Review and Meta-analysis. Obstet Gynecol. 2022 Nov 1;140(5):769-777. doi: 10.1097/AOG.0000000000004962. Epub 2022 Oct 5. PMID: 36201787.

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