Leptin gene polymorphisms are associated with high risk of cardiovascular disease

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The findings of a recent study on leptin polymorphism (LEP) has shown a close association with coronary heart disease (CAD), high body mass index (BMI), and obesity.

The result of this study was published in the journal, Hormone Molecular Biology and Clinical Investigation. It included 18,984 subjects taken from eleven studies.

Based on the results of the study, it was found that three polymorphisms of the leptin gene, namely G-2548A, rs7799039, and A19G are known to increase the chances of having cardiovascular disease. An individual who is homozygous dominant for G-2548A polymorphism carries a greater risk of developing heart disease, high BMI, and obesity.

Thereby, it maybe concluded that leptin gene polymorphisms can increase chances of cardiovascular disease and related conditions.

Source: Khaki-Khatibi F, Shademan B, Gholikhani-Darbroud R, Nourazarian A, Radagdam S, Porzour M. Gene polymorphism of leptin and risk for heart disease, obesity, and high BMI: a systematic review and pooled analysis in adult obese subjects. Horm Mol Biol Clin Investig. 2022 Sep 15. doi: 10.1515/hmbci-2022-0020. Epub ahead of print. PMID: 36103664.


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