When a disorder has affected more than one person in a particular family, that particular disorder it is described to be running in a family.
Some disorders that affect multiple family members are caused by gene alterations that can be inherited from a parent to a child/children.
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Heart diseases such as heart attack, heart failure, and stroke tend to run in the family.
And some examples of single-gene hereditary disorders include: Cystic fibrosis, sickle-cell anemia, Marfan syndrome.